Phenol is C6H5OH. It alone is toxic, as are certain phenol compounds. However, phenols are also found in many healthful fruits, vegetables, herbs, seeds and nuts. And certain phenols are, variously, important in normal metabolism, including metabolism of adrenal stress hormones; in countering oxidative stress, inflammation and toxicity; and, possibly, as a protective agent in diabetes, cancer, and aging.
Phenols include flavonoids (the coloring matter in plant foods, known for antioxidant and anti-inflammatory properties), resveratrol (in grape skin), tocopherols (vitamin E), carotenoids (which have vitamin A-like activity), and salicylates (this guide lists salicylate-rich foods), as well as the flavoring compound in raspberries, the agent which makes cayenne hot, the source of the smoky/ pungent scent in many perfumes, and a breakdown product of hemoglobin.
Sulfation of Phenols
Phenol accumulation, however, presents toxicity issues. Normally, a process called sulfation* attaches sulfate to the phenols in food and chemicals, making them less toxic, and facilitating elimination. Specifically, the enzyme, PST (phenol sulfur-transferase), sulfo-conjugates phenols, creating phenol-sulfates.
The basic chemistry is: phenols --via PST-- yield phenol-sulfates
* Sulfation is also one of the major processes in liver detox activity, targeting various compounds, not just phenols.
Too few sulfates, too many phenols, or downregulation of PST allows phenols to accumulate instead of being detoxed and eliminated via sulfation. Thus, phenol sensitivity is a good indicator of sulfation problems.
Sulfation also seems to be needed to metabolize or regulate estrogen and adrenal stress hormones.
In summary, a lack of sulfates, subfunctional sulfo-transferases, and too many phenols and amines taxing the system, leads to phenol and amine accumulation, often producing sensitivity. (See Rosemary Waring, PhD, on amine sensitivity), This biochemistry also increases overall toxicity, excitotoxicity, and oxidative stress, with profound effects on brain function. Moreover, inadequate sulfation prevents the body from adequately removing stimulating neurotransmitters and hormones, thereby increasing the tendency to anxiety, insomnia and mania.
Other mental and physical symptoms:
Delusions, phobias, dysperceptions, feelings of unreality, perhaps hallucinations.
Sensitivity to light and sound, ringing in the ears. Dark circles under the eyes.
Sleep problems, night sweats.
Memory and concentration problems, episodes of blank mind, disorientation, vertigo.
Socialization problems (associated with low CCK activity).
The following physical symptoms:
Rash, eczema, red face, hives, feeling of something crawling on the skin, other skin conditions.
Frequent urination or urinary retention, dehydration.
Nausea, gastrointestinal symptoms, gall bladder problems.
Hyperventilation, tachycardia, racing pulse, breathing issues, excess or suppressed perspiration.
Muscle or joint aches. Migraines.
Migraines, allergies, chemical sensitivity.
Perhaps, Alzheimers, Parkinsons, motor neurone disease, or cirrhosis.
(Similar to whats found in histadelia.)
Urinary loss of potassium and sodium bicarbonate.
Toxic metal buildup. Problems eliminating toxins.
Low plasma sulfate, often high urinary levels.
TREATMENT APPROACHES (Petryka, Roberts, and here)
B6 can inhibit PST, but generally supports sulfoxidation. Adverse symptoms reduced if 1:1 with magnesium. (See: Rosemary Waring, PhD)
Other B vitamins are often useful.
Epsom salt bath or cream, as relevant. (See Kurt Woeller, DO)
Additional sulfate sources such as taurine and glucosamine sulfate may or may not help. Similarly, for sulfur foods. Avoid sulfites.
Pancreatic digestive enzymes (suppressed by low sulfate), which break down fats, proteins, nucleic acids and carbs, as relevant.
Enzymes which digest veggies, fruits, nuts and grain (e.g., breaking down xylose, cellulose, glucans, phytins, galactose, and carbs), as relevant.
Possibly, baking soda. (Interesting anecdote on suggestions by Rich Van Konynenburg, PhD)
Possibly, cranberry juice (anecdotal). (John Petryka, ND)
Supporting sulfation after long impaired can cause intolerable detox reactions and discourage use of nutrients needed for healing. Which is why certain nutrients (even glutathione) may have to be introduced gradually.
Boron (found in apples pears, legumes, nuts, leafy greens, grapes) interferes with phenol breakdown.
* Oranges, spinach, radish, grapefruit, beet, pepper, squash, vanillan, tomato, food color as well as flavonoids, inhibit sulfating enzymes.
Nevertheless, such foods and nutrients clearly convey important health benefits, so are restricted mainly at the beginning of treatment (until reasonable sulfation can be established), and mainly to the extent to which they are causing significant adverse symptoms.
Restrictions vary with the individual. People commonly react to certain foods, but not others. Reactive foods may need to temporarily be avoided or, at least, eaten less frequently, and in smaller amounts. Eventually though, with enough sulfation support, reactivity should diminish enough so that most such foods can be eaten in reasonable quantities.
See also, previous post.
Reminder: This information is presented for educational purposes only, and is not intended as diagnosis or treatment recommendations for the individual. Even within the histadelic subgroup, each person's biochemical requirements tend to be unique. So if you need treatment for depression, mania, bipolar, or any other medical condition, please consult a knowledgeable physician.