1 They are already overloaded in folic acid.
2 Histadelics do not readily turn folic acid into methyl folate, which is needed to support neurotransmitter methylation. Instead folic acid accumulates, worsening histadelic depression.
So the focus of therapy becomes: restrict folate, and support brain methylation (see previous posts).
Note: We are talking here only of histadelics, that is, people with undermethylation of brain neurotransmitters, and already elevated folate. For almost everyone else with mood problems, folic acid tends to be essential.
For more information, see my book, Natural Healing for Bipolar Disorder.
Reminder: This information is presented for educational purposes only, and should not be construed as treatment recommendations. If you need treatment for histadelia, bipolar, or any other medical condition, please consult a knowledgeable physician.