Histadelics (undermethylated, high folate individuals) can be either high, low or normal thyroid. What follows is a possible association between undermethylation and autoimmune thyroid.1 Undermethylation is commonly associated with low glutathione
Almost all histadelics are low in glutathione, a critical antioxidant, because:
— An efficiently functioning methylation cycle is needed to supply precursors of glutathione as well as other important sulfur antioxidants.
— Also, in some, due to specific problems in feedback mechanisms between the methylation cycle and transsulfuration pathway.
2 Low glutathione may foster thyroid autoimmunity
The thyroid uses hydrogen peroxide to create thyroid hormones. Glutathione peroxidase then detoxes the hydrogen peroxide. If glutathione is lacking, however, the hydrogen peroxide, a potent free radical, will react with thyroid proteins. The immune system may then fail to recognize these altered proteins as normal constituents of the thyroid, and launch an autoimmune attack. C Duthoit (2001)
suggests this scenario as a possible etiology of autoimmune thyroid.
In this vein, Dr. Rich van Konynenburg reports that thyroid function improved markedly in a number of his chronic fatigue, autoimmune hypothyroid patients, upon methylation and glutathione support. They find glutathione stimulating, perhaps due to enhancement of thyroid function
-- suggesting caution with glutathione during episodes of thyroid hyperactivity (and perhaps mania) that can occur with early thyroid autoimmunity.
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