Homocysteine --via methyl folate + methyl B12-- yields methionine
See: Diagram of the methylation cycle.
Here is what is supposed to happen:
Folic acid --methylene-tetrahydro-folate-reductase + SAM-- yields a methyl-folate (5-MTHF)
Folic acid is methylated by 5-MTHF-R to create 5-MTHF (methylene-tetrahydro-folate), a methyl folate, the active form of folic acid.
Homocysteine --via methionine synthase + methyl B12*-- yields Methionine
Methyl is transferred from 5-MTHF to B12, creating methyl-B12 (methyl-cobalamin).
The enzyme, methionine synthase, transfers the methyl from methyl-B12 to homocysteine, converting it into methionine.
* Or via the betaine (trimethylglycine) pathway: HCY + TMG yields Methionine + DMG
Why should histadelics limit folic acid?
Therapeutic approaches (Walsh)
External methyl sources are given to ramp up the methylation cycle:
Methionine, SAMe, increased dietary methyl, as relevant.
Supplemental methyl B12 (or betaine, if indicated) may be needed to insure that homocysteine is metabolized to methionine.
Again, supplemental folic acid is not recommended as it will just increase already high levels of folate.
Note: If folic acid is not excessive, restriction is harmful to health and is not indicated.
Next post: Histadelia, B12 and glutathione
For more info on histadelia and bipolar disorder, see my book, Natural Healing for Bipolar Disorder
Reminder: This information is presented for educational purposes only, and is not intended as diagnosis or treatment recommendations for the individual. Even within the histadelic subgroup, each person's biochemical requirements tend to be unique. So if you need treatment bipolar disorder, or any other medical condition, please consult a knowledgeable physician.