VI.d. Histamine, hyperthyroid, undermethylation

Many histadelics (undermethylated, high histamine and folate individuals) experience overactive thyroid (others, underactive). Possible mechanisms for the elevated thyroid found in some histadelias:

Histamine can increase thyroid hormone. 

Histamine triggers TRH release, increasing thyroid hormones.
The thyroid, in turn, may block histamine degradation and increase sensitivity to histamine, worsening the histadelia.*  (Mariano)
* On the other hand, it can reduce mast cells, and decrease histamine release.

The low NE activity, common in histadelia, can increase thyroid hormones.

Norepinephrine (NE) and thyroid have the same precursor, tyrosine. The relation between NE and thyroid can be reciprocal, with elevated thyroid compensating for decreased NE.  (Swann,
Becker)

Autoimmune thyroid, which may be due histadelia, can initially cause sporadic hyperthyroidism.

See  VI.b. Autoimmune thyroid, histadelia and glutathione


Note: Thyroid status can also be largely independent of the histadelia.

For a wider view of thyroid, histadelia, and bipolar disorder, you may want to see my book, Natural Healing for Bipolar Disorder
                available here.

To contact me, click here.

VI.d. Thyroid / Histamine Interactions

Chronic elevated histamine is one of the chief means of diagnosing histadelia, the most common biotype in bipolar disorder. Histamine interactions with the thyroid are complex, and not well-explored. Here is some food for thought:

The thyroid can either increase or decrease histamine:

— The thyroid may suppress the brain's histamine release and decrease its histamine-containing mast cells.
— Or increase body sensitivity to histamine and block its degradation.
 Sabria 1987, Uhpadhyaya, 1993,  Mariano 2009

Histamine may alter thyroid function

Histamine is known to strongly influence hypothalamus regulation of cellular metabolism, energy production and food intake. The thyroid is a major target gland in hypothalamic governance of  metabolism and energy production.
 Elmhar 2006,  Sakata 1997, Masaki 2001

Allergies and associated histamine release may be hard on the thyroid

Allergic reactions, which cause the profuse mast cells of the thyroid to dump histamine, and perhaps iodine, may thereby interfere with thyroid function. (Elmhar, Do low thyroids suffer more with allergies?)

Histamine may contribute to thyroid autoimmunity

Histamine-releasing antibodies are often found during increased thyroid autoimmunity, suggesting histamine may contribute to the immune attack on the thyroid (Mariano, 2009) -- perhaps via inflammation and increased permeability. (Melander 1975)


For a more comprehensive view of thyroid, histamine, and bipolar disorder, you may want to see my book, Natural Healing for Bipolar Disorder
                available here.

To contact me, click here.

Reminder: This information is presented for educational purposes only, and is not intended as diagnosis or treatment recommendations for the individual. Each person's biochemical requirements tend to be unique. So if you need treatment for bipolar, thyroid disorder or any other medical condition, please consult a knowledgeable physician.