For info on vitamin approaches for histapenia (brain overmethylation, low folic acid), a biotype affecting up to 25% of bipolars, especially when more prone to mania or paranoia, see my Natural Healing for Schizophrenia blog at http://naturalhealingforschizophrenia.blogspot.com/
Check posts June 25, 2013 to Sept 19. (More to follow shortly.)
You can find the complete rundown in either of my books, Natural Healing for Bipolar Disorder or Natural Healing for Schizophrenia, available at http://boragebooks.com
Questions? You get a free educational consult when you buy my book at http://boragebooks.com
Showing posts with label bipolar methylation. Show all posts
Showing posts with label bipolar methylation. Show all posts
Tuesday, January 7, 2014
Friday, February 10, 2012
Histadelia and Methylation. Part IB. What is Methylation?
Methyl is CH3, a carbon with three attached hydrogens.
Methylation, simply put, is the addition of methyl to a molecule.
An example: Serotonin is methylated to form melatonin.
Low catecholamines and serotonin. Undermethylation of both the dopamine/norepinephrine cycle and the serotonin cycle often leads to low levels of these neurotransmitters.
Folic acid accumulation. Since folic acid is not being easily methylated into its more active form, it tends to accumulate.
What the methylation cycle does:
1. Provides methyl to create phosphatidylcholine, melatonin, epinephrine, carnitine, Co-Q10, creatine, and other molecules critical to mental and physical functioning.
2. Helps govern (usually silencing) gene expression (the process by which DNA manifests the directives encoded within it, by causing specific proteins or RNA to be produced).
3. Helps regulate the formation of taurine, cysteine, glutathione and other sulfur molecules.
Methylation, simply put, is the addition of methyl to a molecule.
An example: Serotonin is methylated to form melatonin.
The connection to histadelia
High histamine. Methylation is needed to
metabolize histamine. When insufficient, histamine accumulates. An inherited tendency to
brain under-methylation seems to be a major cause of histadelia.Low catecholamines and serotonin. Undermethylation of both the dopamine/norepinephrine cycle and the serotonin cycle often leads to low levels of these neurotransmitters.
Folic acid accumulation. Since folic acid is not being easily methylated into its more active form, it tends to accumulate.
What the methylation cycle does:
1. Provides methyl to create phosphatidylcholine, melatonin, epinephrine, carnitine, Co-Q10, creatine, and other molecules critical to mental and physical functioning.
2. Helps govern (usually silencing) gene expression (the process by which DNA manifests the directives encoded within it, by causing specific proteins or RNA to be produced).
3. Helps regulate the formation of taurine, cysteine, glutathione and other sulfur molecules.
Both the neurotransmitter under-methylation and the elevated histamine contribute to histadelic characteristics.
For more info, see my book, Natural Healing for Bipolar Disorder
For more info, see my book, Natural Healing for Bipolar Disorder
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