Histapenia (overmethylation low folate)

For info on vitamin approaches  for histapenia (brain overmethylation, low folic acid), a biotype affecting up to 25% of bipolars, especially when more prone to mania or paranoia, see my Natural Healing for Schizophrenia blog at http://naturalhealingforschizophrenia.blogspot.com/
Check posts June 25, 2013 to Sept 19. (More to follow shortly.)
You can find the complete rundown in either of my books, Natural Healing for Bipolar Disorder or Natural Healing for Schizophrenia, available at http://boragebooks.com
Questions? You get a free educational consult when you buy my book at http://boragebooks.com

IV. Bipolar Creativity: Chemistry and Vitamins

Bipolar chemistry may foster creativity.

It may be that the increased brain stimulation in mania (and positive-symptom schizophrenia) helps provide that particular blend of openness, obsession, intensity, and altered perception which fuels creativity (or provides the insights to be expressed during calmer states).

Thus, methylation imbalances, heightened activity of dopamine, norepinephrine, serotonin, histamine, thyroid, pituitary, etc.; and/or increased receptor sensitivity to such biochemicals may contribute not only to mania or psychosis, but also, creativity.

Perhaps all "creatives" have a little bit of bipolar (or schizophrenia) in them.

Perhaps "creatives" not diagnosed with bipolar or schizophrenia also manifest some of the above chemistry, but possess greater balancing mechanisms--better defense against oxidative stress and toxins, more balanced methylation activity, more accurate metal metabolism, more efficient use of calming nutrients; stabler hormone homeostasis, etc. Or, perhaps, just more optimal intake of supportive nutrients.

Why heal?

Are  extreme moods intrinsic to creativity? Possibly, however, family members, people who have similar genetics but not evident bipolar or schizophrenia, can be particularly creative. On the other hand, studies suggest that bipolar I individuals often begin -- but do not complete -- creative endeavors.
Does one need extremes of irritability, paranoia, isolation, recklessness, and confusion to be creative?

What about a healing approach that nourishes the brain, rather than coercing it, an approach that enables the brain to optimize function with needed nutrients... Consider that the late and great Dr. Abram Hoffer, who had worked with over 10,000 patients, has said something to the effect that people who recover with orthomolecular treatment no longer have the adverse symptoms, but just seem to be more creative that everyone else.

To learn more about nutrient-based approaches, see my books, Natural Healing for Bipolar Disorder, and Natural Healing for Schizophrenia, here
Buy at boragebooks.com. and you also get a free educational consult.

Reminder: The information in this blog is presented for educational purposes only, and is not intended for diagnostic or treatment purposes. If you need treatment for mood disorder or any other medical condition, please consult a knowledgeable physician.

III. Bipolar Biotypes and Creativity

Biotype creative tendencies 

Doctors William Walsh, PhD, (2006, 2007) and Carl C Pfeiffer,  (1987, 1988), who have overseen nutrient-based treatment of approximately 20,000 psych patients each, have noted particular types of creativity associated with biotype.

Histapenia. Artistic or musical interest/creativity. (Pfeiffer 87, 88, Walsh 2006)

Histadelia.  Often perfectionist, competitive, compulsively productive and creative, highly accomplished (Pfeiffer); and frequently excels in science, business, and left brain activity. (Walsh)

Pyroluria. Pfeiffer has stated that pyrolurics are among his most original patients and that many great people were pyroluric, despite the mental anguish and physical deterioration caused by the illness.

For descriptions of these biotypes, corresponding nutrients, and relevance to bipolar, see my book, Natural Healing for Bipolar Disorder.
Get a free educational consult (by phone) when you purchase from http://boragebooks.com/orderBooks.html

This is the third in a series on bipolar and creativity.

Bipolar Depression: Histadelia Vitamins II

Nutrients commonly used for histadelic bipolars include:
SAMe, methionine, vitamin B6, magnesium and TMG, as per individual requirements. See:  the sample histadelia page from Natural Healing for Bipolar Disorder (as per my previous post).

Further histadelia nutrients can include:

Calcium — often depleted. Calcium decreases histamine and supports release of antidepressant neurotransmitters.
Inositol — may reduce anxiety, promote sleep. Critical to signalling. Counterbalances choline and supports folate, vitamin B6, vitamin B12, betaine and methionine.  Too much may promote anxiety or panic in some bipolars, but not usually histadelics.
Methyl  B12 — Needed to turn homocysteine to methionine. Especially critical if oxidative stress is prevalent.
Omega 3 — supports methylation.
Niacinamide — modest amounts, introduced gradually, with attention to reactions. If voices occur,  B3 tends to be crucial. Anxiety may also signal greater need.
Zinc — Counters overstimulation. Supports homocysteine metabolism to cysteine or methionine.

Antioxidant support. With undermethylation, oxidative stress increases, and further compromises methylation pathways and depletes neurotransmitter precursors. Consider the following antioxidants:
Glutathione — of prime importantce. Needed to support formation of methyl B12.
Selenium and E — works with glutathione.
Vitamin C — decreases histamine; moderates stimulation; antidepressant.
Vitamin A — helps counter the seasonal allergies.
Vitamin D — supports calcium absorption and helps counter depression. 
Acetyl-L-carnitine — a great mitochondrial antioxidant; need may be suggested by low mental energy. However, may overstimulated.
Other antioxidants, as relevant.

Other nutrients, sometimes indicated 
Serotonin support (e.g, St Johnswort, tryptophan, 5HTP) — modest intake may help balance mood, especially if depleted.
Kava — calms limbic activation, but overstimulating for some.
Tyrosine — may  temporarily help counter the depression, especially if depleted, at least until methylation increases.
Copper — supports dopamine and norepinephrine formation, decreases histamine. In histadelics, metal metabolism disorders tends toward overactivity, decreasing copper. If so, small doses,  in some cases, may become useful (but not if it worsens oxidative stress).

Diet

Plentiful quality animal proteins (preferably fish from mercury-free waters; organic meats, free-range poultry) provide methionine. A good whole foods diet is recommended, with lots of complex carbohydrates and vegetables (though intake of greens, in some cases where folate is too high, needs to be moderated), healthy fats, and some fresh fruit. Minimize/avoid immunoreactive foods. Dairy provides calcium, which the histadelic needs, but is commonly an allergen (if so, consider goat milk products and a possible need for more zinc). Avoid sugar, white flour, fried and hydrogenated fat.

Restrictions 
Folic acid, is typically excessive relative to methylation status, so often must be significantly restricted.
Choline (which counterbalances norepinephrine) may worsen histadelic depression, so may need to be limited. DMAE, especially, tends to be detrimental,
GABA often is less than helpful during low-catecholamine histadelic depression.

This material reflects approaches developed by Doctors: Walsh, Hoffer, Pfeiffer, Jaffe, Kruesi, Bibus, and others.  See Natural Healing for Bipolar Disorder for further info, including contraindications and references

Reminder: These are general summaries presented to educate the public and are not treatment recommendations. Treatment depends on the individual's unique biochemistry and response pattern. Attention to contraindications is essential.  If you need treatment for histadelia, bipolar, or any other medical condition, please consult a knowledgeable physician.